Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer(Scientific Reports (2015) 5: (10442) 10.1038/srep10442)

NA Al-Tassan; N Whiffin; FJ Hosking; C Palles; SM Farrington; SE Dobbins; R Harris; M Gorman; A Tenesa; BF Meyer; SM Wakil; B Kinnersley; H Campbell; L Martin; CG Smith; S Idziaszczyk; E Barclay; TS Maughan; R Kaplan; R Kerr; D Kerr; DD Buchanan; AK Win; J Hopper; M Jenkins; NM Lindor; PA Newcomb; S Gallinger; D Conti; F Schumacher; G Casey; MG Dunlop; IP Tomlinson; JP Cheadle; RS Houlston

Journal article

Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer(Scientific Reports (2015) 5: (10442) 10.1038/srep10442)

NA Al-Tassan, N Whiffin, FJ Hosking, C Palles, SM Farrington, SE Dobbins, R Harris, M Gorman, A Tenesa, BF Meyer, SM Wakil, B Kinnersley, H Campbell, L Martin, CG Smith, S Idziaszczyk, E Barclay, TS Maughan, R Kaplan, R Kerr Show all

Scientific Reports | NATURE PORTFOLIO | Published : 2015

DOI: 10.1038/srep12372

Abstract

Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), imputing genotypes utilising the 1000 Genomes Project. The combined analysis identified new, significant associations with CRC at 1p36.2 marked by rs72647484 (minor allele frequency [MAF] = 0.09) near CDC42 and WNT4 (P = 1.21 × 10−8, odds ratio [OR] = 1.21 ) and at 16q24.1 marked by rs16941835 (MAF = 0...

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